The ability of FRJS to control fiber arrangements in three dimensions offers a streamlined approach to fabricating tissues and organs, with this work demonstrating how helical architectures contribute to cardiac performance. Seeding these scaffolds with cardiomyocytes enabled the biofabrication of tissue-engineered ventricles, with helically aligned models displaying more uniform deformations, greater apical shortening, and increased ejection fractions compared with circumferential alignments. The heart is situated within the chest cavity and surrounded by a fluid-filled sac called the pericardium. The halves are, in turn, divided into four chambers.
It is divided by a partition (or septum) into two halves.
Here we report focused rotary jet spinning (FRJS), an additive manufacturing approach that enables rapid fabrication of micro/nanofiber scaffolds with programmable alignments in three-dimensional geometries. The heart is the organ that helps supply blood and oxygen to all parts of the body. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features and complex structures of the heart’s musculature using current techniques. There is a semilunar valve where the aorta leaves the left ventricle and another where the pulmonary artery leaves the right ventricle.Abstract:Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. The semilunar valves stop the back flow of blood into the heart. The bicuspid valve is located between the left atrium and left ventricle and likewise opens due to a build-up of pressure, this time in the left atrium. The tricuspid valve is located between the right atrium and right ventricle and opens due to a build-up of pressure in the right atrium. The septum separates the right-hand and left-hand side of the heart. The ventricles pump the blood out of the heart to the lungs or around the body. The atria (plural of atrium) are where the blood collects when it enters the heart. The left-hand side pumps oxygenated blood around the body.Įach side of the heart consists of an atrium and a ventricle which are two connected chambers. The right-hand side of the heart is responsible for pumping deoxygenated blood to the lungs. The heart is a large muscular pump and is divided into two halves - the right-hand side and the left-hand side. It is located in the middle of the chest and slightly towards the left. If you clench your hand into a fist, this is approximately the same size as your heart.
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